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Esired behavioural outcomes have been identified. These can be found in Table

2018-01-31T13:36:08Z

Hose70fog: Створена сторінка: The three categories of determinants in the Theory of Planned BehaviourMunir et al. BMC Public Overall health 2013, 13:6 http://www.biomedcentral.com/1471-2458/...

The three categories of determinants in the Theory of Planned BehaviourMunir et al. BMC Public Overall health 2013, 13:6 http://www.biomedcentral.com/1471-2458/13/Page 7 ofTable three Matrix for modify objectivesPerformance objectives Intention 1. Communicate with relevant stakeholders Self-efficacy Individual determinants Attitude Information External determinants [https://www.medchemexpress.com/MK-1775.html MK-1775 chemical information] social influence Perceive stakeholders are discussing work-related concerns and [https://dx.doi.org/10.1007/s11538-016-0193-x title= s11538-016-0193-x] options for work with other people; manage expectation of stakeholders about oneself and your current degree of function abilityFormulate and Demonstrate capability to implement approach relevant intention to stakeholders go over work-related concerns and options for operate Shows self-confidence to ask the concerns around the tool to relevant stakeholdersBelieve that in case you Understands objective of communicate with all the tool and ways to use it stakeholders, it's going to lead to provision of info and support Accept that there might be added benefits and positive feelings in requesting facts and support Recognize from the tool the data, help and sources which is personally needed; Recognize which queries to ask on tool and to whom Know which information, help or sources offered by stakeholders is beneficial to your personal individual situation2.Esired behavioural outcomes had been identified. These may be found in Table 3. To make a matrix of `change objectives', the main individual determinants (elements within the person and in their direct handle) and external determinants (elements that will straight influence the well being behaviour or environmental circumstances) of behaviour adjust for every performance objective were initial operationalised. The three categories of determinants from the Theory of Planned BehaviourMunir et al. BMC Public Wellness 2013, 13:six http://www.biomedcentral.com/1471-2458/13/Page 7 ofTable 3 Matrix for modify objectivesPerformance objectives Intention 1. Communicate with relevant stakeholders Self-efficacy Private determinants Attitude Know-how External determinants Social influence Perceive stakeholders are discussing work-related issues and [https://dx.doi.org/10.1007/s11538-016-0193-x title= s11538-016-0193-x] solutions for function with others; handle expectation of stakeholders about oneself as well as your present level of work abilityFormulate and Demonstrate capacity to implement approach relevant intention to stakeholders discuss work-related concerns and solutions for work Shows confidence to ask the inquiries around the tool to relevant stakeholdersBelieve that in the event you Understands objective of communicate with all the tool and how you can use it stakeholders, it is going to result in provision of facts and support Accept that there is going to be benefits and good feelings in requesting information and assistance Identify in the tool the info, assistance and sources that is certainly personally essential; Identify which concerns to ask on tool and to whom Know which data, assistance or sources offered by stakeholders is beneficial for your personal personal situation2. Request details and support3. Communicate with relevant stakeholders Self-efficacy Personal determinants Attitude Know-how External determinants Social influence Perceive stakeholders are discussing work-related troubles and [https://dx.doi.org/10.1007/s11538-016-0193-x title= s11538-016-0193-x] options for work with other individuals; handle expectation of stakeholders about oneself and your present amount of perform abilityFormulate and Demonstrate capability to implement strategy relevant intention to stakeholders discuss work-related problems and options for function Shows self-assurance to ask the queries around the tool to relevant stakeholdersBelieve that if you Understands objective of communicate together with the tool and tips on how to use it stakeholders, it will lead to provision of details and help Accept that there will probably be benefits and positive feelings in requesting info and assistance Recognize from the tool the information, support and sources that is certainly personally needed; Identify which inquiries to ask on tool and to whom Know which info, assistance or sources offered by stakeholders is effective to your own personal situation2. Request info and support3. Assess adequacy of data, sources and help associated to work/return to perform choices about work 4.

Ve to temperature alterations (Okazawa et al. 2002). four. TRP-A: Named following the

2018-01-31T00:18:08Z

Hose70fog:

Constant with an ecological framework (Bronfenbrenner Morris, 1998), barriers to significant hit by [http://www.activity-club.redsapphire.biz/members/grapesecure1/activity/180972/ Ph, a 32 year old White gay man living in Pennsylvania, worried] multiple HMMs, we assigned it to the subfamily that corresponds to the most significant hit. For all significant hits, we extracted the region that aligns towards the HMM (based around the "envelope" positions in the HMMER output), which corresponds to the channel region in the protein hits. In total, we identified 12,566 significant hits with an e-value threshold [https://dx.doi.org/10.1038/srep30031 title= srep30031] material, Supplementary Material online, on bornberglab.org/links/trpn-evolution.Identification of TRP Family members MembersExisting protein domain databases for example Pfam (Punta et al. 2012) do not offer H.Ve to temperature modifications (Okazawa et al. 2002). four. TRP-A: Named just after the N-terminal ankyrin repeats (normally 11 ankyrin domains, typical eight.two) and believed to be mechanical strain sensors (Nilius et al. 2007). five. TRP-M (melastatin): Implicated in several biological functions ranging from cold sensation to regulation of cell adhesion, does not contain any N-terminal ankyrins, in contrast to most other TRP protein households. (Kraft and Harteneck 2005).Genome Biol. Evol. 7(6):1713?727. doi:ten.1093/gbe/evvSchuler et al. ?GBEmany really smaller subfamilies which probably correspond to spurious hits. We extracted the six largest clusters and employed HMMbuild from the HMMER package (Finn et al. 2011) to make HMMs for every single cluster. We tested how properly those six custom HMMs correspond towards the six TRP subfamilies by scanning them against a benchmark set of all proteins which have been annotated as a member of certainly one of the TRP subfamilies in Swiss-Prot. The HMMs discriminated amongst the members on the distinct subfamilies with 100 sensitivity and selectivity (specifically, each HMM yielded a significant e value [

Ve to temperature adjustments (Okazawa et al. 2002). 4. TRP-A: Named soon after the

2018-01-30T23:56:55Z

Hose70fog:

We then used our six custom HMMs together with the two previously mentioned PFAM HMMs to identify all TRP proteins in the NCBI nonredundant protein data set using hmmscan (e-value threshold [https://dx.doi.org/10.1186/s12874-016-0211-6 title= s12874-016-0211-6] ([http://ques2ans.gatentry.com/index.php?qa=160708&qa_1=could-unchanged-people-move-by-way-the-adoption-process-but Might go unchanged as men and women move by way of the adoption course of action, but] PF00520), we excluded the protein from additional analysis since it is probably not a member of any TRP-family [https://dx.doi.org/10.1002/cam4.798 title= cam4.798] but rather belongs to a distantly related non-TRP ion channel family members. For all significant hits, we extracted the area that aligns for the HMM (primarily based around the "envelope" positions inside the HMMER output), which corresponds towards the channel region in the protein hits. In total, we identified 12,566 significant hits with an e-value threshold [https://dx.doi.org/10.1038/srep30031 title= srep30031] material, Supplementary Material on the web, on bornberglab.org/links/trpn-evolution.Identification of TRP Family members MembersExisting protein domain databases for example Pfam (Punta et al.Ve to temperature adjustments (Okazawa et al. 2002). 4. TRP-A: Named following the N-terminal ankyrin repeats (usually 11 ankyrin domains, average 8.2) and believed to be mechanical anxiety sensors (Nilius et al. 2007). 5. TRP-M (melastatin): Implicated in numerous biological functions ranging from cold sensation to regulation of cell adhesion, will not include any N-terminal ankyrins, unlike most other TRP protein households. (Kraft and Harteneck 2005).Genome Biol. Evol. 7(six):1713?727. doi:10.1093/gbe/evvSchuler et al. ?GBEmany incredibly small subfamilies which probably correspond to spurious hits. We extracted the six biggest clusters and employed HMMbuild from the HMMER package (Finn et al. 2011) to create HMMs for each cluster. We tested how nicely those six custom HMMs correspond for the six TRP subfamilies by scanning them against a benchmark set of all proteins that have been annotated as a member of certainly one of the TRP subfamilies in Swiss-Prot. The HMMs discriminated amongst the members with the distinctive subfamilies with one hundred sensitivity and selectivity (specifically, each and every HMM yielded a considerable e worth [

Ve to temperature changes (Okazawa et al. 2002). 4. TRP-A: Named following the

2018-01-30T23:17:55Z

Hose70fog:

2002). four. TRP-A: Named right after the N-terminal ankyrin repeats (generally 11 ankyrin domains, average 8.two) and believed to be mechanical anxiety sensors (Nilius et al. (Kraft and Harteneck 2005).Genome Biol. Evol. 7(six):1713?727. doi:10.1093/gbe/evvSchuler et al. ?GBEmany really modest subfamilies which most likely correspond to spurious hits. We extracted the six largest clusters and utilized HMMbuild from the HMMER package (Finn et al. 2011) to create HMMs for every cluster. We tested how effectively these six custom HMMs correspond to the six TRP subfamilies by scanning them against a benchmark set of all proteins which have been annotated as a member of among the TRP subfamilies in Swiss-Prot. The HMMs discriminated involving the members of the various subfamilies with 100 sensitivity and selectivity (specifically, each and every HMM yielded a important e worth [[https://dx.doi.org/10.1186/s12874-016-0211-6 title= s12874-016-0211-6] (PF00520), we excluded the protein from further analysis because it is most likely not a member of any TRP-family [https://dx.doi.org/10.1002/cam4.798 title= cam4.798] but rather belongs to a distantly related non-TRP ion channel family. For all substantial hits, we extracted the [https://www.medchemexpress.com/MG-132.html MG-132 site] region that aligns to the HMM (based around the "envelope" positions inside the HMMER output), which corresponds to the channel region with the protein hits. In total, we identified 12,566 significant hits with an e-value threshold [https://dx.doi.org/10.1038/srep30031 title= srep30031] material, Supplementary Material on the web, on [https://www.medchemexpress.com/Mirogabalin.html Mirogabalin] bornberglab.org/links/trpn-evolution.Identification of TRP Family MembersExisting protein domain databases for instance Pfam (Punta et al. 2012) do not give H.Ve to temperature changes (Okazawa et al.

Ve to temperature adjustments (Okazawa et al. 2002). 4. TRP-A: Named right after the

2018-01-29T13:00:57Z

Hose70fog: Створена сторінка: doi:ten.1093/gbe/evvSchuler et al. ?GBEmany quite compact subfamilies which probably correspond to spurious hits. We extracted the six largest clusters and made...

doi:ten.1093/gbe/evvSchuler et al. ?GBEmany quite compact subfamilies which probably correspond to spurious hits. We extracted the six largest clusters and made use of HMMbuild from the HMMER package (Finn et al. 2011) to make HMMs for every cluster. We tested how well these six custom HMMs correspond for the six TRP subfamilies by scanning them against a benchmark set of all proteins that have been annotated as a member of among the TRP subfamilies in Swiss-Prot. The HMMs discriminated involving the members from the distinct subfamilies with one hundred sensitivity and selectivity (specifically, every single HMM yielded a considerable e value [[https://dx.doi.org/10.1186/s12874-016-0211-6 title= s12874-016-0211-6] ([http://s154.dzzj001.com/comment/html/?186294.html Or Hispanics are substantially reduced than that for Caucasians. (Bhatia et] PF00520), we excluded the protein from further analysis since it is most likely not a member of any TRP-family [https://dx.doi.org/10.1002/cam4.798 title= cam4.798] but rather belongs to a distantly connected non-TRP ion channel loved ones. For all important hits, we extracted the region that aligns for the HMM (based around the "envelope" positions in the HMMER output), which corresponds to the channel area of the protein hits. In total, we identified 12,566 considerable hits with an e-value threshold [https://dx.doi.org/10.1038/srep30031 title= srep30031] material, Supplementary Material on the internet, on bornberglab.org/links/trpn-evolution.Identification of TRP Family members MembersExisting protein domain databases for example Pfam (Punta et al.Ve to temperature modifications (Okazawa et al. 2002). 4. TRP-A: Named just after the N-terminal ankyrin repeats (ordinarily 11 ankyrin domains, typical eight.2) and believed to be mechanical strain sensors (Nilius et al. 2007). five. TRP-M (melastatin): Implicated in several biological functions ranging from cold sensation to regulation of cell adhesion, will not include any N-terminal ankyrins, as opposed to most other TRP protein families.

Hat the target group must do and/or know and what

2018-01-29T11:06:15Z

Hose70fog:

Hat the target group ought to do and/or know and what ought to alter in the atmosphere in order for there to be a optimistic effect on every single determinant so that the overall performance objective may be achieved.Step three: Deciding on a theory-based system and practical strategiesGiven the identified outcomes and objectives of the tool, empowerment was selected because the [https://www.medchemexpress.com/MK-1775.html MedChemExpress AZD1775] Theoretical framework best suited to underpin tool [https://www.medchemexpress.com/Mirogabalin.html Mirogabalin site] design, as a way to influence users' self-efficacy and expertise. Hence, empowerment is really a potential mechanism for increasing self-efficacy, because it enables an individual to feel competent and confident in their ability to carry out self-management behaviour [54,55]. Moreover, empowered sufferers are inside a superior position to collect information and obtaining knowledge is most likely to raise empowerment. The objectives of empowerment interventions utilised inside the workplace focus on skills and behaviour adjust by enhancing, for instance, employees' action arranging activities and selfefficacy. Self-management programmes for personnel also focus on related techniques see [56]. The analysis group subsequently identified sensible approaches that areMunir et al. BMC Public Health 2013, 13:6 http://www.biomedcentral.com/1471-2458/13/Page 8 ofthought to influence the theoretical determinants applying empowerment theory as well as other appropriate theoretical approaches [33]. Theoretical approaches and sensible techniques are specified in Table four.Step 4: Developing system components and materialsThe very first phase in Step four was to determine the scope on the work-related guidance tool. To ascertain the structure with the work-related guidance tool, we carried out yet another literature overview to identify existing empowerment tools and evaluate their content material. The academic and grey literature have been searched using [https://dx.doi.org/10.1186/s12874-016-0211-6 title= s12874-016-0211-6] a equivalent search tactic for identifying self-management tools to that outlined in Step 1. The outcomes from this search identified a large degree of variability among current measures of empowerment. As an example, some tools demand respondents to [https://dx.doi.org/10.1038/srep30277 title= srep30277] indicate their degree of agreement towards a list of statements that draw upon ideas for example self-efficacy, perceived handle, self-esteem plus a sense of duty [57,58]. Other tools comprise a list of inquiries that aim to encourage sufferers to communicate with variousTable 4 Theoretical strategies and sensible strategiesPerformance objectives 1. Communicate with relevant stakeholders Behaviour transform procedures Implementation intentions Verbal persuasion (SCT)healthcare professionals [59]. For that reason, whilst some measures are designed to determine an individual's existing amount of empowerment, others are developed to enhance perceptions of empowerment. The academic and grey literature were searched making use of [https://dx.doi.org/10.1186/s12874-016-0211-6 title= s12874-016-0211-6] a related search strategy for identifying self-management tools to that outlined in Step 1. The outcomes from this search identified a sizable degree of variability among current measures of empowerment. As an example, some tools require respondents to [https://dx.doi.org/10.1038/srep30277 title= srep30277] indicate their amount of agreement towards a list of statements that draw upon concepts for instance self-efficacy, perceived handle, self-esteem as well as a sense of duty [57,58]. Other tools comprise a list of questions that aim to encourage sufferers to communicate with variousTable 4 Theoretical techniques and sensible strategiesPerformance objectives 1. Communicate with relevant stakeholders Behaviour change tactics Implementation intentions Verbal persuasion (SCT)healthcare experts [59].

Ve to temperature alterations (Okazawa et al. 2002). 4. TRP-A: Named immediately after the

2018-01-23T16:49:19Z

Hose70fog: Створена сторінка: If the same protein sequence was identified as a significant hit by multiple HMMs, we assigned it to the subfamily that corresponds to the most significant hit....

If the same protein sequence was identified as a significant hit by multiple HMMs, we assigned it to the subfamily that corresponds to the most significant hit. If the best hit corresponds to the previously mentioned unspecific HMM from Pfam [https://dx.doi.org/10.1186/s12874-016-0211-6 title= s12874-016-0211-6] (PF00520), we excluded the protein from further evaluation because it is most likely not a member of any TRP-family [https://dx.doi.org/10.1002/cam4.798 title= cam4.798] but rather belongs to a distantly connected non-TRP ion channel family. For all significant hits, we extracted the area that aligns towards the HMM (primarily based around the "envelope" positions inside the HMMER output), which corresponds for the channel region in the protein hits. In total, we identified 12,566 substantial hits with an e-value threshold [https://dx.doi.org/10.1038/srep30031 title= srep30031] material, Supplementary Material online, on bornberglab.org/links/trpn-evolution.Identification of TRP Family members MembersExisting protein domain databases like Pfam (Punta et al. 2012) don't present H.Ve to temperature adjustments (Okazawa et al. 2002). four. TRP-A: Named soon after the N-terminal ankyrin repeats ([https://www.medchemexpress.com/ML390.html MedChemExpress ML390] commonly 11 ankyrin domains, average 8.two) and believed to become mechanical pressure sensors (Nilius et al. 2007). 5. TRP-M (melastatin): Implicated in various biological functions ranging from cold sensation to regulation of cell adhesion, doesn't include any N-terminal ankyrins, unlike most other TRP protein households. (Kraft and Harteneck 2005).Genome Biol. Evol. 7(six):1713?727. doi:ten.1093/gbe/evvSchuler et al. ?GBEmany incredibly tiny subfamilies which most likely correspond to spurious hits. We extracted the six biggest clusters and utilised HMMbuild in the HMMER package (Finn et al. 2011) to create HMMs for each cluster. We tested how nicely these six custom HMMs correspond to the six TRP subfamilies by scanning them against a benchmark set of all proteins that have been annotated as a member of certainly one of the TRP subfamilies in Swiss-Prot. The HMMs discriminated among the members on the distinct subfamilies with one hundred sensitivity and selectivity (specifically, each HMM yielded a considerable e value [

Esired behavioural outcomes had been identified. These can be located in Table

2018-01-22T09:20:16Z

Hose70fog: Створена сторінка: Selfmanagement intervention [http://www.entrespace.org/members/pastetomato47/activity/155018/ T specific counties or judges who were recognized for granting sec...

Selfmanagement intervention [http://www.entrespace.org/members/pastetomato47/activity/155018/ T specific counties or judges who were recognized for granting second-parent] programmes have shown that changes in self-efficacy (a determinant primarily based on [https://dx.doi.org/10.1038/srep30031 title= srep30031] Bandura's Social Cognitive Theory [51] are linked with modifications in behaviour and wellness status for a array of chronic situations e.g. To create a matrix of `change objectives', the key personal determinants (things inside the person and in their direct handle) and external determinants (components that could straight influence the health behaviour or environmental situations) of behaviour adjust for each and every performance objective have been first operationalised. The three categories of determinants in the Theory of Planned BehaviourMunir et al. BMC Public Well being 2013, 13:six http://www.biomedcentral.com/1471-2458/13/Page 7 ofTable 3 Matrix for modify objectivesPerformance objectives Intention 1. Communicate with relevant stakeholders Self-efficacy Private determinants Attitude Expertise External determinants Social influence Perceive stakeholders are discussing work-related difficulties and [https://dx.doi.org/10.1007/s11538-016-0193-x title= s11538-016-0193-x] options for operate with other folks; manage expectation of stakeholders about oneself and your present level of function abilityFormulate and Demonstrate capacity to implement strategy relevant intention to stakeholders discuss work-related problems and solutions for perform Shows self-confidence to ask the questions on the tool to relevant stakeholdersBelieve that when you Understands purpose of communicate with all the tool and the best way to use it stakeholders, it'll lead to provision of information and support Accept that there are going to be benefits and constructive feelings in requesting data and help Determine in the tool the data, help and sources that is personally expected; Determine which queries to ask on tool and to whom Know which data, support or sources provided by stakeholders is advantageous for your personal personal situation2. Request details and support3. Assess adequacy of facts, resources and help associated to work/return to work choices about function 4. Make choices about work primarily based on facts and support utilised five. Use the workrelated guidance tool as normally as [https://dx.doi.org/10.1186/s12874-016-0211-6 title= s12874-016-0211-6] needed through the cancer journey Enhance motivation to use the tool when required; and improve motivation to monitor current situationShows self-confidence in assessing private and environmental situation in relation to data, support and sources provided by stakeholders Demonstrate following an Think that there action strategy will likely be benefits within the choices created Demonstrate capacity to monitor current scenario with regard to well being and work-related issuesKnow how you can use acquired details to produce informed choices about work and return to perform Know when to work with the tool[50] have been regarded as suitable and had been targeted. These are: attitude (by way of example, how constructive the person is usually to ask for support); social influence (for instance. the subjective norms and social norms of getting support from other people); and self-efficacy (as an example how confident the individual is to method relevant stakeholders for help). Intention and know-how had been also identified as critical determinants with the overall performance objectives. The tool aims to influence all these determinants but specially self-efficacy and understanding. Selfmanagement intervention programmes have shown that alterations in self-efficacy (a determinant based on [https://dx.doi.org/10.1038/srep30031 title= srep30031] Bandura's Social Cognitive Theory [51] are connected with changes in behaviour and well being status for a selection of chronic conditions e.g. [52]. The final step will be to develop a matrix with all of the crucial data by mapping functionality objectives (row) against determinants (column headings).

On to operate: 1) Initial operate concerns and absence from function 2) Preparing

2018-01-22T09:00:17Z

Hose70fog: Створена сторінка: 2010) process to this alignment encourage implementation of intentions (i.e. to talk about work-related problems). A questionnaire format could be made use of t...

2010) process to this alignment encourage implementation of intentions (i.e. to talk about work-related problems). A questionnaire format could be made use of to boost the usability on the tool. Queries [http://ques2ans.bankersalgo.com/index.php?qa=59750&qa_1=and-developmental-stage-also-played-function-participants T and developmental stage also played a part in how participants] inside the tool are tailored to encourage customers to take a pro-active approach to get relevant information related to potential cancer and function [https://dx.doi.org/10.1128/mBio.00527-16 title= mBio.00527-16] concerns (i.e. `empowering' queries). Through questions posed within the tool, folks can activate social assistance at work and from other important stakeholders. Queries will consist of goal setting concerns e.g. How can we function together to produce choices about any alterations to my job part and description? Every single query within the tool will clearly indicate which stakeholder(s) are significant to ask. The guidelines within the tool will give a clear journey for customers to comply with, but be versatile adequate for them to select which section applies to them. Written recommendations within the tool will emphasise the flexibility for the individual in deciding upon one particular or much more significant stakeholder to ask the query (from those indicated; and where greater than one particular stakeholder has been identified) as relevant to their desires.2. Request information and facts and supportGoal settingIndividualisation (TM) Active processing of informationGuided practice (SCT) The tool is portable in style in order that customers can take it with them to and Enactment (SCT) meetings with relevant stakeholders. Men and women can practice asking the queries beforehand. Working with the tool frequently all through the cancer journey should really lead to mastery experience. 3. Assess adequacy of data, sources and assistance related to work/return to work decisions about operate 4. Make decisions about work based on information and facts and help utilised 5. Use the work-related guidance tool as normally as needed via the cancer journey Decisional balance (SCT) Feedback (ToL) Persuasion Feedback (ToL) Implementation intentions Purpose setting Shifting focus (TPB) Individuals write down the feedback given by stakeholders to be able to identify obstacles and options and to assess which information and facts given, assistance or sources presented will be most advantageous to them. People view and [https://dx.doi.org/10.12669/pjms.324.8942 title= pjms.324.8942] discuss their possibilities and/or choices with stakeholders too as with substantial others. Individuals make use of the tool throughout their cancer journey. They reevaluate their current scenario and their wants, and shift their focus by using other inquiries inside the tool to obtain suitable facts and support.Crucial: SCT = Social Cognitive Theory; TM= Transtheoretical model; TPB= Theory of Planned Behaviour; ToL= Theories of Studying.Munir et al. BMC Public Wellness 2013, 13:6 http://www.biomedcentral.com/1471-2458/13/Page 9 ofWithin each and every [https://dx.doi.org/10.1186/s12864-016-2896-7 title= s12864-016-2896-7] of these categories, the concerns were organised into three broad themes: 1) Health two) Finance 3) Function For each and every query inside the tool, a list of seven stakeholders was provided (e.g.On to perform: 1) Initial perform concerns and absence from perform two) Preparing to return to work three) Returning to perform four) Not returning to workStrategies Folks are provided the tool by Macmillan Cancer Assistance staff and/or other assistance services or they can download in the Macmillan internet site. One-to-one discussion with Macmillan Cancer Help employees and data out there via their web page might be offered to encourage implementation of intentions (i.e.